产品货号：
Z17266
中文名称：
GFI1B抗体
英文名称：
Anti-GFI1B Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GFI1B Antibody (C-term) |
| 指标别名 | Zinc finger protein Gfi-1b,Growth factor independent protein 1B,Potential regulator of CDKN1A translocated in CML,GFI1B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | GFI1B |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This GFI1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B. |
| 计算分子量 | 37kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages.Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses,via histone deacetylase (HDAC) recruitment,a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.Transcriptional repressor or activator depending on both promoter and cell type context;represses promoter activity of SOCS1 and SOCS3 and thus,may regulate cytokine signaling pathways.Cooperates with GATA1 to repress target gene transcription,such as the apoptosis regulator BCL2L1;GFI1B silencing in leukemic cell lines markedly increase apoptosis rate.Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells.Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription;as GATA1 also mediates erythroid GFI1B transcription,both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells.Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction.Binds to gamma-satellite DNA and to its own promoter,auto-repressing its own expression.Alters histone methylation by recruiting histone methyltransferase to target genes promoters.Plays a role in heterochromatin formation. |
| Uniprot ID | Q5VTD9 |
相关搜索：GFI1B抗体，GFI1B(C-term)多抗，Anti-GFI1B Antibody (C-term)